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Synthesis of Novel Nitrogen Mustards Containing Amino Alcohol Derivatives

Aïcha. Amira, Malika. Berredjem, and Nour-Eddine. Aouf
Laboratory of Applied Organic Chemistry (LAOC), Bioorganic Chemistry Group, Chemistry Department, Sciences Faculty, Badji-Mokhtar-Annaba University, Box 12, 23000 Annaba, Algeria

Abstract—Nitrogen mustards are an extremely active class of alkylating agents that have widespread clinical application in the treatment of various tumors. A Novel series of 1,1-bis(2-chloroethyl)-3-(2-hydroxy ethyl)urea 3(a-c) having different substituent on C-2 have been synthesized from a number of simple and chiral amino alcohols derivatives prepared by reduction of amino acids. Nitrogen mustard motif is introduced by acylation of bis (2-chloroethyl) amine with ethyl chloroform ate in water. The aminolysis of ethyl ester with a variety of amino alcohols in solvent-free conditions is the key step to give the desired products. All structures of the compounds were analyzed by different spectroscopic methods.

Index Terms—nitrogen mustard, acylation, amino alcohol, aminolysis

Cite: Aïcha. Amira, Malika. Berredjem, and Nour-Eddine. Aouf, "Synthesis of Novel Nitrogen Mustards Containing Amino Alcohol Derivatives," Journal of Life Sciences and Technologies, vol. 3, no. 2, pp. 65-68, December 2015. doi: 10.18178/jolst.3.2.65-68

 
 
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