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Crystal Growth and Physical Characterization of Acyclovir Crystallized with Ascorbic Acid and Zinc Chloride

Montha Meepripruk 1, Ratree Bumee 1, Weenawan Somphon 2, and Pek-Lan Toh 3
1. School of Chemistry, Kampheang Phet Rajabhat University, Kampheang Phet, Thailand
2. Chemistry Department, Kasetsart University Kampheangsean, Nakhon Pathom, Thailand
3. Abdul Rahman, Faculty of Engineering and Green Technology, Perak, Malaysia

Abstract—Acyclovir is the API in the most common antiviral drug used for treatment of HSV and VZV infections. Advantages for acyclovir are low cytotoxicity and low HSV resistance as well as the availability of low cost generic forms. Disadvantages include low bioavailability, perhaps partially due to low solubility. Herein, we present cocrystallization of acyclovir with ascorbic acid and zinc chloride forming a new complex. Acyclovir was separated from an acyclovir drug and the cocrystals of 1:1:1 acyclovir-ascorbic acid-ZnCl2, ACV-ASc-Zn) were screened by slow evaporation via solution-based methods under 10 solvents. Successful cocrystal forms in the solvent isopropanol-water (1:2). Physical properties were characterized by SEM/EDX, FT-IR and TGA.

Index Terms—crystal growth, acyclovir, ascorbic acid, Zinc chloride

Cite: Montha Meepripruk, Ratree Bumee, Weenawan Somphon, and Pek-Lan Toh, "Crystal Growth and Physical Characterization of Acyclovir Crystallized with Ascorbic Acid and Zinc Chloride," Journal of Life Sciences and Technologies, vol. 4, no. 2, pp. 56-59, December 2016. doi: 10.18178/jolst.4.2.56-59
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